The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon ResistanceArticle Published on 2022-12-142023-07-10 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] furin cleavage site IFITM SARS-CoV-2 Type 1 interferon. VoC [DOI] 10.1128/jvi.01250-22 PMC 바로가기
Breakthrough Gastrointestinal COVID-19 and Intrahost Evolution Consequent to Combination Monoclonal Antibody ProphylaxisArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] amino acid change antiviral therapy Breakthrough infection Colon Consequent COVID-19 Deletion furin cleavage site Gastrointestinal gastrointestinal tract Infection intestinal low-dose monoclonal antibody mucosa mucosal nonhuman primates promote Prophylaxis rectal swab Replication rhesus SARS-CoV-2 suboptimal prophylaxis. tissue upper respiratory viral evolution viral replication Viral RNA virus virus stock [DOI] 10.1093/infdis/jiac134 PMC 바로가기
Intranasal administration of cold-adapted live-attenuated SARS-CoV-2 candidate vaccine confers protection against SARS-CoV-2Article Published on 2022-10-022022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 진단, [키워드] administration animal model attenuate Attenuated vaccines can be used candidate vaccine cleavage COVID-19 COVID-19 pandemic Deletion elicit examined furin cleavage site furin protease glycoprotein hamster hamsters histopathological Host Immunity Infection lesion motif mucosal neutralizing antibody parental pathogenesis of SARS-CoV-2 polybasic protective immunity proteolytic reduce required robust S1/S2 S1/S2 glycoprotein SARS-CoV-2 SARS-CoV-2. sequence Spike protein subsequent suggested unique Vaccine virus wild-type WT SARS-CoV-2 [DOI] 10.1016/j.virusres.2022.198857 PMC 바로가기
Artificial Neural Network-Based Study Predicts GS-441524 as a Potential Inhibitor of SARS-CoV-2 Activator Protein Furin: a Polypharmacology ApproachArticle Published on 2022-10-012022-11-15 Journal: Applied biochemistry and biotechnology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activator ANN Antiviral antiviral drug antivirals artificial Bacterial Bacterial infection Cancer caused Compound COVID-19 diabetes DNA drug Drug repurposing ENhance FCGR1A FDA furin furin cleavage site Grazoprevir GS-441524 help human protein inhibit inhibiting inhibitor inhibitors LB-VS LDLR mammalian MK-5172 network pharmacology Neural Neurological disorders pandemic Patient PCK1 PNP polybasic Polypharmacology Potential researcher SARS-CoV-2 SB-VS searched SOM. substrate target the spike protein TLR7 turn Virtual screening virus virus [DOI] 10.1007/s12010-022-03928-2 PMC 바로가기
Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycleSARS-CoV-2 스파이크 단백질 요소와의 Decavanadate 상호 작용은 감염 주기를 방해하는 정전기의 잠재적 역할을 강조합니다Article Published on 2022-09-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral agent approach association binding biological properties biological property carried collected data coronavirus COVID-19 cytotoxicity decrease disrupt disrupting drug design effective Effectiveness effort electrostatic force electrostatic forces element ENhance Evidence furin furin cleavage site highlight Host host cell host cell membrane identify In vitro studies in vitro study infected cells Interaction interactions less mass spectrometry molecular Native Novel coronavirus Polyanion polybasic Polyoxidometalate Protein Protein binding Proteolytic processing provide receptor Receptor-binding domain robust robustness Safe SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 spike protein shown Spike protein the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic therapeutic agent therapeutic agents Therapeutics utility Vanadium Vanadium. variety Viral mutations while [DOI] 10.1016/j.jinorgbio.2022.111899 PMC 바로가기 [Article Type] Article
Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in UgandaArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] A.23.1 activated Activation Affect Alpha variant analyzed appearance arginine B.1.1.7 B.1.617 B.1.617.2 cell-cell fusion change changes changes in cleavability cleavage Context Course delta variant functional functional consequences furin furin cleavage site host cell Identified increase in infectivity assay less Lineage mimicking Mutation natural selection notable occur occurred P681R P681R mutation pandemic Particle Pathogenesis peptide performed position 681 predicted proline protease pseudotyped S1/S2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike significantly increased spike spike gene Spike protein Spike. Spread Surveillance the SARS-CoV-2 Transmissibility transmitted Uganda variant viral variant virus virus [DOI] 10.1128/spectrum.01514-22 PMC 바로가기
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis푸린 절단 부위의 QTQTN 모티프는 SARS-CoV-2 감염 및 발병에 중요한 역할을 합니다Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] attenuate cleavage coronavirus CoVs Critical cultured virus deleting Deletion determine disease Disruption Efficiency Factor FCS furin furin cleavage site furin-cleavage site glycosylated glycosylation host proteases in vitro in vivo Infection isolates less motif mutant Pathogenesis peptide QTQTN reduced required residue residues respiratory respiratory cell respiratory cells S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein Spike protein Spike. the SARS-CoV-2 TMPRSS2 upstream Viral viral replication virus replication [DOI] 10.1073/pnas.2205690119 PMC 바로가기 [Article Type] Article
Evolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein족자카르타와 인도네시아 중부 자바에서 순환하는 SARS-CoV-2의 진화 역학: 스파이크 단백질의 푸린 절단 부위(FCS) 영역을 포괄하는 서열 분석Article Published on 2022-08-012022-09-11 Journal: International microbiology : the official journal [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis cDNA cDNA synthesis circulating clade Cluster Clusters confirmed COVID-19 patients coronavirus COVID-19 pandemic COVID-19 patient D614 variant D614G D614G mutation evolutionary dynamics FCS FIVE furin furin cleavage furin cleavage site G614 variant Genome GISAID indicated Indonesia Mutation Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples new SARS-CoV-2 new virus PCR amplification Protein Q677H Region replaced responsible retrieved RNA SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates sequence Sequence analysis Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 silent spike Spike protein spike protein. synthesis the spike protein were used [DOI] 10.1007/s10123-022-00239-8 PMC 바로가기 [Article Type] Article
A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection스파이크와 뉴클레오캡시드를 발현하는 변형된 백시니아 앙카라 백신은 SARS-CoV-2 Delta 감염으로부터 붉은털 원숭이를 보호합니다Article Published on 2022-06-242022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] added Beta Beta variant binding Blood CD4 CD8 T cell correlated cross-reactive cross-reactive antibody Delta delta variant Efficacy elicited expressed expressing FCS function furin furin cleavage site Heterologous homologous human ACE2 humoral IgG inactivated inactivation induce Infection intramuscular less lung mice moderate neutralized Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody nose nucleocapsid positively correlated PROTECT rectum response rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 vaccines secretion serum spike spike-specific IgG T cell T cell response T cell responses tested the SARS-CoV-2 vaccination Vaccine variant variants of concern virus VoC VOCs [DOI] 10.1126/sciimmunol.abo0226 PMC 바로가기 [Article Type] Article